Complete remission of chemo‐refractory multiple‐metastatic upper tract urothelial carcinoma by autologous formalin‐fixed tumor vaccine
نویسندگان
چکیده
A patient with chemo-refractory multiple-metastatic upper tract urothelial carcinoma (UTUC) treated by monotherapy with autologous formalin-fixed tumor vaccine (AFTV) resulted in complete remission of the lung and para-aortic lymph node metastases (ongoing >3 years after AFTV). The tumor was immunohistologically negative for PD-L1. AFTV will be an attractive treatment option.
منابع مشابه
A transient increase and subsequent sharp decrease of chemo‐refractory liver‐metastasized uterine cervical small cell carcinoma to autologous formalin‐fixed tumor vaccine plus anti‐PD‐1 antibody
Uterine cervical small cell carcinoma is rare and aggressive with no standardized therapy. A patient bearing the advanced chemo-refractory carcinoma, treated with a tumor vaccine combined with 1 mg/kg of pembrolizumab, showed a transient increase and subsequent sharp decrease of the liver-metastasized lesion to less than half its maximum diameter.
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OBJECTIVE The p21-activated kinase serine/threonine kinases have been outlined as the main cytoskeletal remolding regulators. The same holds true for cell proliferation and motility. They additionally have a part in cellular invasion and carcinogenesis, but the effect of p21-activated kinase 1 expression on the progression of upper urinary tract urothelial carcinoma remains unclear. Therefore, ...
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